Borussia Dortmund and Feyenoord, who contested the 2002 UEFA [ Images ] Cup final, were dumped out of this season's competition at the second-round stage.
On a bad night for German clubs, Schalke also exited on penalties to end Bundesliga interest in the UEFA Cup, though Bayern Munich [ Images ] could still end up in the competition if they finish third in their Champions League [ Images ] group.
Dortmund, Champions League winners in 1997, were humiliated by French club Sochaux, going down 4-0 for a 6-2 aggregate defeat.
Their cause was not helped when Salvatore Gambino was dismissed after five minutes for hauling down Santos in the area and Pierre-Alain Frau converted the penalty.
Second-half goals from Santos, Wilson Oruma and Jeremy Mathieu completed a miserable night for the Bundesliga club.
Schalke, the 1997 UEFA Cup winners, were protecting a 2-1 lead against Danish side Brondby but fell behind after 15 minutes when Andreas Jakobsson scored from the penalty spot.
Victor Agali equalised after the break but a Mattias Jonson goal in the 70th minute took the game into extra time before a penalty shootout sealed Schalke's fate.
Dutch club Feyenoord, who won the competition in 2002 and 1974, were humbled by Czech outsiders Teplice. Despite gaining a 1-1 away draw, the damage had been done in a 2-0 defeat in Rotterdam two weeks ago.
Liverpool and Newcastle United maintained English interest in the third round after 1-0 home victories over Steaua Bucharest and FC Basel respectively, but Manchester City [ Images ] were knocked out on away goals following a 0-0 draw in Poland against Groclin Grodzisk.
Spanish clubs fared well with Barcelona [ Images ], Real Mallorca [ Images ] and Villarreal [ Images ] all progressing.
Barcelona's 2-0 home victory over Panionios completed a 5-0 aggregate win, Mallorca advanced despite being held 1-1 by FC Copenhagen, and Villarreal scraped through despite a 1-0 defeat at Torpedo Moscow [ Images ].
Serie A club Parma bounced back from a weekend defeat by lowly Empoli to thrash Salzburg 5-0 and complete a 9-0 aggregate victory, Benito Carbone scoring twice.
AS Roma were pushed harder, however, needing a late goal from Antonio Cassano to knock out Croatian side Hajduk Split.
Red Star Belgrade, the 1991 European Cup winners, were eliminated by Norwegian champions Rosenborg Trondheim, losing 1-0 in front of a stunned 53,000 crowd.
Russians Spartak Moscow also suffered a shock 3-1 defeat at Dinamo Bucharest, but went through 5-3 on aggregate.
After Turkey's elimination from Euro 2004 qualifying, Gaziantepspor and Genclerbirligi restored pride with impressive away victories.
Gaziantepspor won 3-1 in Lens for a 6-1 aggregate thrashing of the French club, while Genclerbirligi eliminated Sporting Lisbon [ Images ] with a 3-0 victory.
Benfica [ Images ], however, did keep the Portuguese flag flying with a 2-0 win at Norway's Molde for a 5-1 aggregate success.

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